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1960-ih: vitamin A i retin A pokazali su učinkovitost u liječenju akni, što je dovelo do razvoja izotretionina, koji se tijekom 1980-ih u SAD-u prodavao kao Accutane i RoaccutaneNakon nestanka rana prouzročenih aknama mogu ostati mali ožiljci koji mogu biti i neuočljivi golim okom.The use of antimicrobial peptides against C. acnes is below in